Takchlor-DX (Eye/Ear Drops)
“AN ANTIBIOTIC WITH EXTRAORDINARY EFFECTS AGAINST MICROBIAL INFECTIONS”
Composition:
Polymyxin B Sulphate 5000 IU, Chloramphenicol 1%, Dexamethasone Sodium
Phosphate Eq. to Dexamethasone Phosphate 0.1% w/v, Phenylmercuric Nitrate 0.001% (As Preservative)
Mode of Action:
Polymyxin B sulfate in Takchlor DX Eye/Ear Drops interacts with the lipo-polysaccharide present in the cytoplasmic outer membrane of Gram-negative bacteria (Pseudomonas aeruginosa), and dissolves the fatty acid region of the cytoplasmic membrane. This ultimately alters the membrane permeability causing the leakage of cell constituent resulting in bacterial cell death.
Chloramphenicol in Takchlor-DX Eye/Ear Drops is bacteriostatic and binds to the bacterial ribosome thereby blocking peptidyl transferase responsible for chain elongation in the process of Protein Synthesis thus resulting in bacterial cell death. Having broad spectrum and is active against many bacterial strains including Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli.
It fulfills its function through multiple pathways, it binds with the corticosteroid receptors and alters the protein synthesis thus prevents the leukocyte infiltration at the site of inflammation, interferes in the function of the mediators responsible for the inflammatory response, suppresses the humoral immune responses and reduction in edema or scar tissue. The anti-inflammatory actions of dexamethasone involve phospholipase A2 inhibitory proteins which control the biosynthesis of potent mediators of inflammation such as prostaglandins.
Steroid Responsive inflammatory conditions of Bacterial conjunctivitis, Bacterial blepharitis, superficial ocular as well as auditory canal bacterial infections caused by susceptible organisms.
- Pseudomonas aeruginosa
- Enterobacter aerogenes
- Streptococcus pneumoniae
- Klebsiella pneumoniae
- Escherichia coli
- Haemophilus influenzae
- Neisseria species
- Staphylococcus aureus
Ocular Dosage: Instill 1-2 drops of Takchlor DX Eye/Ear Drops into the affected eye (s) for ever two hours initially and 5-6 times a day in case of improvement decrease the dosage consulting your Eye Doctor.
Otic Dosage: Instill 1-2 drops of Takchlor DX Eye/Ear Drops into the affected Ear Canal for 4-5 times a day .
- Do not swallow solution.
- If solution changes color or becomes cloudy, do not use.
- To avoid contamination, do not touch bottle tip on any surface and avoid direct contact with the eye.
- Close the bottle tightly immediately after use.
- Hypersensitivity towards any of the component.
- Growth of Resistant Organisms with Prolonged Use.
- Contraindicated In patients with corneal lesions herpes simplex keratitis, viral and fungal infection.
- Prolonged use may cause glaucoma or cataract.
Adverse Effects:
Temporary Burning, Stinging, Irritation, Itching, Redness, Blurred Vision and Light sensitivity or allergic reaction may occur.