MOXITAK-D(RGB)
MOXITAK-D
Composition:
Moxifloxacin Hydrochloride IP
Eq. to Moxifloxacin 0.5% w/w
Dexamethasone Sodium Phosphate IP 0.1% w/w
Sterile Ointment Base
Dosage Form: Ophthalmic Ointment
Pharmacology
MOXIFLOXACIN, in Moxitak-D works as an anti-bacterial
agent Floro-Quinolones exert their antibacterial effect by preventing bacterial
DNA from unwinding and duplicating. Moxifloxacin hydrochloride is a synthetic
8-methoxyfluoroquinolone with a broad spectrum anti-bacterial effect on gram
positive, gram negative and other anaerobic micro-organism. Well tolerated
with minimal ocular side effects and provides increased penetration into ocular
tissues and fluids with improved activity against Streptococci and
Staphylococci species. It has a moderate to excellent activity against clinically
relevant, gram-negative ocular pathogens.
DEXAMETHASONE - is a synthetic analog of naturally occurring
glucocorticoids (hydrocortisone and cortisone). Dexamethasone sodium
phosphate is a water soluble, inorganic ester of dexamethasone and has antiinflammatory
and immunosuppressant effects. It fulfills its function through
multiple pathways, it binds with the corticosteroid receptors and alters the
protein synthesis thus prevents the leukocyte infiltration at the site of
inflammation, interferes in the function of the mediators responsible for the
inflammatory response, suppresses the humoral immune responses and
reduction in edema or scar tissue. The anti-inflammatory actions of
dexamethasone involve phospholipase A2 inhibitory proteins which control
the biosynthesis of potent mediators of inflammation such as prostaglandins.
Indication and Usage: Bacterial Conjunctivitis (pink eye) and Bacterial
Corneal Ulcer Infection caused by susceptible strains of Staphylococcus
species. Bacterial ocular infection associated with bacterial blepharitis.
Precautions: Hypersensitivity towards any of the component in the solution.
: Apply thin strip (about 1cm) of ointment into the
affected eye(s) every 4 hours or as directed by physician.
Information to Patient: Follow the instructions that are provided by your
doctor and if the adverse effect persists, discontinue the usage and contact
your doctor immediately.
Precautions: Hypersensitivity towards any of the component in the solution.
Growth of Resistant Organisms with Prolonged
Use
- Avoidance of Contact Lens Wear
- if irritations persist, discontinue the use and consult the eye doctor
- Prolonged use may result in glaucoma
- Defects in visual acuity and fields of vision
Adverse Effect:
- Nausea, Diarrhea, Dizziness, blurred vision that does not go away, burning,
stinging, or itching of the eyes or eyelids.
- Ocular hyperemia, Ocular pain and Ocular pruritus