Nepafenac in NEPATAK , when rapidly crosses the cornea, then gets deaminated by the internal Hydrolases into an activated form amide analogue, Amfenac, which posts inhibitory effect on the Cyclooxygenase derivatives COX1 & COX2.

As per the literary data, the COX-1 is associated with the inflammation whereas COX-2 is associated with pain. It works as per the NSAID Model, uniformly inhibiting the activity of COX1 and COX2 receptors, responsible for the cascade of inflammatory reactions. The duo plays vital role in the production of Postglandins and Thromboxane from Arachidonic acid through a series of reactions. The latter two are responsible for the series of actions take place in during the inflammation, like pain, itching, redness, discharges, etc.

Treating Inflammation And Pain Associated With Cataract Surgery, Acute Pseudophakic, Chronic Pseudophakic, And Recalcitrant Uveitic Cystoid Macular Edema (CME).

• Prolonged use NSAIDS may cause Keratitis.
• May slow or delay healing.
• It should not be administered, wearing contact lenses.
• In the case of corneal breakdown, discontinue the usage and contact your Eye Doctor.
• Contraindicated is hypersensitive to the contents of the ophthalmic solution.

Adverse Effect:

Decreased visual acuity, a feeling that something is in the eye, increase in IOP, sticky sensation, headache, ocular stinging or vision change.