TOLAR-LD is a sterile solution combination of two active ingredients i.e. Ketorolac Tromethamine a non-steroidal anti-inflammatory agent with analgesic- antipyretic activity and Dexamethasone a glucocorticoids an unique combination for ocular use. TOLAR-LD works by blocking the production of prostaglandins responsible for inflammation and pain along with prevention of tissues from responding to inflammation. As per literary data combination of NSAID and GLUCOCORTICOID is therapeutically well tolerated and effective drug. Combination of these two have therapeutically benefits because they sequen tially block the arachidonic acid cause production of prostaglandins along with prevention of Cystoid macular edema which mainly occur post cataract surgery and individually NSAID cannot give measurable effect.

KETOROLAC TROMETHAMINE- KETOROLAC TROMETHAMINE contains S- and R- enantiomeric forms, in which S-form shows analgesic activity. KETOROLAC functions by inhibiting both COX-1 and COX-2 which further inhibits prostaglandins synthesis by inhibiting the precursor of prostaglandins from arachidonic acid. As a results reduces inflammation.

DEXAMETHASONE SODIUM PHOSPHATE- DEXAMETHASONE functions by binding to glucocorticoid receptors and make complex, this complex further binds to DNA element and modified transcription process and protein synthesis which further inhibits the infiltration of leukocytes on the site of inflammation.

TOLAR-LX is indicated to use in the following conditions-

• allergic and bacterial conjunctivitis as combination drug
• inflammation caused from post cataract surgery
• redness, itching and pain

Before using TOLAR-LX eye drop tell your doctor about all kind of allergies, hypersensitivities or allergy from NSAID/aspirin/glucocorticoids for precautionary purpose.

ADVERSE EFFECTS-

• Blurry vision
• corneal edema
• iritis